Transcriptional target-based expression cloning of immunoregulatory molecules

Design, cloning, expression and evaluation of cysteine-substitutes of intact and truncated molecules of streptokinase

Introduction: Thrombosis and the blockage of blood vessels with clots, can lead to acute myocardial infarction and some times even death. Aside from surgical interventions to remove the blockage, the only available treatment is the administration of thrombolytic agents to dissolve the blood clot. Streptokinase (SK) is the most commonly used fibrinolytic drug for this purpose. However, SK...

Cloning, Expression and Characterization of Recombinant Human Fc Receptor Like 1, 2 and 4 Molecules

Background: The Fc receptor like (FCRL) molecules belong to the immunoglobulin (Ig) superfamily with potentially immunoregulatory <span style="font-va...

Cloning and Expression of Leishmania major Superoxide Dismutase B1: A Potential Target Antigen for Serodiagnosis of Leishmaniasis

cloning, expression and characterization of recombinant human fc receptor like 1, 2 and 4 molecules

background: the fc receptor like (fcrl) molecules belong to the immunoglobulin (ig) superfamily with potentially immunoregulatoryfunction. among the fcrl family fcrl2 and 4 are predominantly expressed on memory b cells and fcrl1 is a pan- b cell marker. to date, noligand has been identifid for the human fcrl1, 2 and 4 molecules.objectives: cloning, expression, purifiation and structural analysi...

Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules.

Glutamate-mediated excitotoxicity has been purported to underlie many neurodegenerative disorders. A subtype of glutamate receptors, namely N-methyl-d-aspartate (NMDA) receptors, has been recognized as potential targets for neuroprotection. To increase our understanding of the mechanisms that underlie this neuroprotection, we employed a mouse model of glutamate receptor-induced excitotoxic inju...